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Testing on KA xenografted mice showed that the PNIPAM/GNS structures with AC effectively induced apoptosis both in vivo and in vitro, increasing apoptosis rates and activating caspases more than AC or PNIPAM/GNS alone (Ma et al

Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure

Moreover, recruited neutrophils during the inductions inflammatory phase (first week) will further participate in tissue injury and fibrosis by producing matrix-degrading enzymes such as neutrophil elastase and releasing excessive ROS 12