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Tat leads to neuronal death by activating calcium release from IP3-sensitive intracellular pools, causing endolysosomal dysfunction and dendritic impairments, which ultimately contribute to spatial memory impairment and premature brain aging [154,155,156,157,158]

Peptides such as CM15 (KWKLFKKIGAVLKVL, synthetic) and MM63:CHx37 from bacteria, also induce oxidative stress by generating superoxide, hydroxyl radicals, and hydrogen peroxide, especially under aerobic conditions, while LL-37 (LLGDFFRKSFKKLGKRLLRFFLSKSA, human) causes oxidative stress by interfering with the cytochrome oxidase-bd complex in the periplasm [126]

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doi: 10.1016/j.molmet.2024.101944 154 Martinez-MedinaMAldeguerXLopez-SilesMGonzlez-HuixFLpez-OliuCDahbiGet al

doi: 10.7150/thno.46006