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The microbiota establishes a bi-directional communication network with the brain via neural, endocrine, and metabolic signaling modalities, hence the popular reference to the microbiome-gut-brain axis (Figure 1)

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Medication was 10 g/kg BPC 157, 10 ng/kg BPC 157, or 5 mL/kg saline, given intraperitoneally, intragastrically, or as bath to the swollen brain above the sinus, at 15 min ligation-time, and recording (with a camera attached to a VMS-004 Discovery Deluxe USB microscope (Veho, Dayton, OH, USA)) performed through next 10 min time

Mol Psychiatry 28:217229