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Results FA excess or B 12 deficiency delays the generation and/or migration of cortical upper layer projections neurons To test the effects of gestational maternal folate/B 12 intake on the offspring, we created five nutritional groups of C57BL/6NJ dams that were fed amino acid defined rodent chow (Dyets Inc., Bethlehem, PA): (1) control, (2) high FA, (3) low B 12 , (4) high FA/low B 12 , and (5) high 5-FTHF

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[0220] In general, the compounds of the present invention may be prepared as illustrated in the general reaction schemes described below, or by modifications thereof, using readily available starting materials, reagents, and conventional synthesis procedures, or could be inferred by one skilled in the art

The presence of the reducing agents will break disulfide bonds between cysteines