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This condition occurs when irritation or compression of the sciatic nerve - the largest nerve in your body - combines with general lower back discomfort

Zhang K, Wu L, Zhang P, Luo M, Du J, Gao T, et al

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Approximately 20% of patients with primary ovarian insufficiency (POI) have been diagnosed with other autoimmune diseases, often thyroid, adrenal, and pancreatic diseases, and approximately 10% of patients with Addisons disease develop POI (16)

These findings suggest that the response to Tofacitinib treatment may vary among patients with different genetic backgrounds