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Chen C, Zhou Y, Hu C, Wang Y, Yan Z, Li Z, et al

Taking L-theanine could inadvertently relax the blood vessels too much, exacerbating orthostatic intolerance and dizziness

Some are: Mechanistic - based on how drugs and supplements act at receptors or metabolism pathways Case reports - single or small numbers of people show a signal worth noting Clinical trials - larger human studies that may demonstrate an effect For L-carnitine, the best evidence links to thyroid hormone action in humans

BDNF exerts its effects by binding to the TrkB receptor, activating downstream signaling pathways such as the PI3K/Akt and MAPK/ERK pathways, which promote cell survival and synaptic plasticity (Ma et al., 2013)