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Glutathione S transferase: A keystone in Parkinson's disease pathogenesis and therapy ScienceDirect Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson's model Cell Death & Disease G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis: Cell Reports Glutathione and neurodegenerative diseases: immunopharmacological implications PMC Frontiers Therapeutic potential of neuroprotective plant extracts in Parkinson's disease

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In addition, the degradation of intracellular GPX4 through CMA pathways can lead to the accumulation of intracellular phospholipid peroxide and ferroptosis, and host cells usually use GPX4 for peroxide phospholipids reduction, thus protecting cells from death