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We will try to restore the wild-type cellular phenotype by transfecting the cells with wild-type GPX4 gene, over-expressing wild-type GPX4 protein, and silencing the mutant protein

The Small Business Technology Transfer (STTR) program followed in 1992 with the same structure, but with an added requirement that the small business team up with a nonprofit research institution

These effects, observed in animal models, have been linked to improvements in muscle physiology and cardiac performance

doi: 10.3389/fimmu.2026.1735598 Received 30 October 2025 Revised 03 February 2026 Accepted 04 February 2026 Published 18 February 2026 Volume 17 - 2026 Edited by Diego Kauffmann-Guerrero, LMU Munich University Hospital, Germany Reviewed by Anthony De Soyza, Newcastle University, United Kingdom Susanne Nhrig, LMU Munich University Hospital, Germany Updates Copyright 2026 Yu, Zhu, Jin, Ding and Jin