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Patients with severe COPD also have elevated plasma levels of ET-1, which is probably related to their chronic hypoxemia 36

Clinical relevance of sarcopenia in chronic kidney disease

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The underlying mechanisms may involve the stimulation of pancreatic -cells, regulation of glucagon levels, and modulation of glucose metabolism (He et al., 2019)

Metabolic microplate-based assays can be divided in two categories: the ones that exploit metabolic activity as an indirect readout and the ones that directly target specific pathways