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The aged mouse study involved small sample sizes

Chandel, N

[15] Venous or arterial thrombosis or thromboembolism including deep vein thrombosis, pulmonary embolism, cerebral thrombosis, acute renal cortical necrosis, and central retinal artery and vein obstruction (e.g., retinal thrombosis) have been rarely reported during postmarketing surveillance of tranexamic acid

DS patients contain approximately 50% higher SOD1 levels in various DS cells and tissues, including erythrocytes, brain, fibroblasts, B and T lymphocytes, which leads to chronic OS and manifests as a wide array of neurological symptoms (Turrens, 2001