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rat testis: degeneration Lowest relevant NOAEL 2 mg/kg bw per day in two 2-year studies, rat Carcinogenicity Not carcinogenic in mice or rats Genotoxicity Not genotoxic Reproductive toxicity Reproductive target/critical effect None

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The main pathology of neurodegenerative diseases, including Alzheimers diseases (AD), Parkinson diseases (PD), amyotrophic lateral sclerosis (ALS) and the polyglutamine (ploy Q) diseases, is a low level of autophagy and accumulation of misfolded proteins and damaged organelles in neurocyte [10]

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