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Advanced analytical techniques detect the reversible oxidation of many proteins involved in cell signaling pathways important for the proliferation and survival of cancer cells

Using an ERE-luciferase mouse, a reporter mouse that allows monitoring of ER transcriptional activity in a spatiotemporal manner, it was demonstrated that estrogen signaling is locally activated in keratinocytes in vitro (with 1 nM E2) and in vivo (with 10 nM E2)

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Furthermore, the overall improvement was also visually evident in global macroscopic images captured at the baseline, 1-month, and 2-month visits [Figure 3]