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4.1.2 Curcumin Curcumin is natural polyphenol found in turmeric

Draganov et al

Notably, models trained with both MAGs and isolates performed significantly better (two-sided Wilcoxon rank-sum test, P 0.5% to any known isolate

Importantly, multiple independent studies have observed that pro-inflammatory cytokines can induce behavioral deficits, mood disorders, and cognitive impairments via monoamine and acetylcholine dysfunction, glutamate elevation, neuroendocrine activation, and impaired neuroplasticity [15, 26]