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The compound is also a potent growth signal for many cell types, which raises real safety questions about long-term use

Top Spinal Cord Inj Rehabil 29(3):113 Kriete A, Mayo KL (2009) Atypical pathways of NF-B activation and aging

These individuals are naturally resistant to R5 HIV infection

The primary cyanogenic glucoside found in cassava, linamarin, liberates glucose and hydrogen cyanide (HCN) following hydrolysis in the gastrointestinal (GI) tract, presumably by the gut flora which harbors the necessary -glucosidase enzyme 6

Subsequent introduction of two random mutations, Y444A and G484A, to D433N EcGGT variant further enhanced catalytic efficiency for GL-7-ACA substrate by 50-fold (Yamada et al., 2008)