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It is noteworthy that FSHR can activate the PKC pathway, which occurs through the formation of IP3 and DAG by FSHR, followed by the cumulus cell proliferation and the oocyte meiotic maturation [64], which indicates the convergence between IGF signaling and gonadotropin GPCRs

The clinical efficacy of infusions for many specific indications, on the other hand, is still under investigation

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Monogenic diabetes in youth with presumed type 2 diabetes: Results from the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration

doi: 10.1007/s00401-016-1545-1 3 MichalskiJMJanssAJVezinaLGSmithKSBillupsCABurgerPCet al