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Basic research supports this mechanism, demonstrating that fructose or HFD exposure induces mitochondrial structural abnormalities, mtDNA depletion, and ATP deficiency, ultimately impairing -oxidation and hepatocyte function

Therapeutic effects of Silibinin against polycystic ovary syndrome induced by Letrozole in rats via its potential anti-inflammatory and anti-oxidant activities

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When to Seek Medical Care Contact your clinician if you experience 3 17: Persistent or worsening right upper abdominal pain Pain after high-fat meals Pain that radiates to the right shoulder or back Nausea or vomiting Fever or chills Yellowing of the skin or eyes (jaundice) Dark urine These signs may indicate active gallstones or a bile duct blockage that requires timely assessment