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Even so, the frequency and significance of these observations are presently unclear

In 2013, a study published in the Journal of Endocrinology and Metabolism evaluated six studies of fragment 176-191 to assess the rate and significance of negative effects associated with the peptide

Hyperpigmentation occurs when patches of skin become darker than the surrounding areas, typically due to an excess production of melanin

These include reactions related to carbohydrate, protein, and fat metabolism and are involved in processes that produce glucose and breakdown glycogen

Strategies to address this include designing biocompatible dendrimers, adjusting surface charges, and applying chemical modifications to mitigate toxicity for clinical applications [201]