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Konstantinidis K, Whelan RS, Kitsis RN (2012) Mechanisms of cell death in heart disease

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In addition to murine models, larger animals such as rabbit, dog, sheep, and bovine have played an important role as their IVDs are more similar in size and mechanical load to human IVDs, particularly in studies involving biomechanical changes over time and the application of pre-clinical therapies (Alini et al., 2008

Another critical challenge is the inherently poor bioavailability of many botanical metabolites, which limits their therapeutic consistency

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