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Since multiple species of Propionibacterium produce no exotoxins or endotoxins and have been granted GRAS status (generally regarded as safe) by the United States Food and Drug Administration, they are the preferred bacterial fermentation organisms for vitamin B 12 production

namely getting their life-giving replacement therapy injection of vitamin B12

Am J Physiol Heart Circ Physiol 293:H677H683

Common signs of a B12 deficiency include: Fatigue Weakness Pale skin Poor coordination Heart palpitations Loss of appetite Unexplained weight loss A B12 deficiency can also contribute to mental health issues like depression and cognitive issues like confusion and poor memory