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J Biochem Mol Toxicol., 2003, 17, 24-38 Giustarinni D,Dalle-Donne I,Colombo R,Petralia S et al

Oral choline increases choline metabolites in human brain

In brain endothelial cells, Centella extracts have demonstrated protective effects against cytokine-induced barrier disruption and reduced MMP-9mediated permeability, suggesting relevance to bloodbrain barrier preservation in CIRS