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doi: 10.1095/biolreprod62.2.439 71 ArablouTAryaeianNKhodaverdiSKolahdouz-MohammadiRMoradiZRashidiNet al

In rodents, activation of AMPA receptors by the KET metabolite (2R,6R)-hydroxynorketamine has initially been thought essential to replicate KET antidepressant effects while administration of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX), an AMPA receptor antagonist, blocks KET effects (Zanos et al., 2016)

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Hays, S

A C20 fatty-diacid moiety enables reversible serum-albumin binding and a markedly extended half-life relative to native incretins, and the balanced dual-receptor activity is what distinguishes it from single GLP-1 agonists like GLP-1 (Sema) and from the triple agonist GLP-3 (Reta)