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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study

Supplementary material The Supplementary Material for this article can be found online at: References 1 BrodeurGM

Hearts were exposed, and ascending aortas were catheterized via the left ventricle