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To assess the potential role of PVN Glu neurons in modulating morphine-induced constipation, we directly infused morphine into the bilateral PVN through implanted cannulas (Fig

doi: 10.1016/j.smim.2007.10.011 33 DuJHuangCZhouBZieglerSF

Savvides P, Nagaiah G, Lavertu P, Fu P, Wright JJ, Chapman R, et al

AMP Kinase (AMPK): AMPK, a key energy-sensing kinase, modulates the activity of glutamine-PRPP amidotransferase to ensure that nucleotide synthesis is in sync with cellular energy status

This approach would allow for precise regulation of HO-1, inhibiting its harmful effects while preserving its antioxidative function