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Effect of direct cold atmospheric plasma (di cap) on microcirculation of intact skin in a controlled mechanical environment

Healing outcomes are dependent on both time and dosage

10.1074/jbc.ra120.013607 98 KawaharaT.LambethJ

Clinical Classification of Chronic Venous Disease C0: No visible or palpable sign of venous disease C1: Spider veins or reticular veins (veins that feed spider veins) C2: Varicose veins C3: Edema (swelling) C4: Changes in skin and tissues A: Pigmentation or eczema B: Thickening, hardening, swelling, redness, inflammation, scarring C5: Healed venous ulcer C6: Active venous ulcer Note: Some potential complications of venous disease, such as DVT, can occur even in people who have no overt signs

early, intermittent, or persistently enhanced cell proliferation and reduced apoptosis