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Moreover, high pretreatment AR abundance was sufficient to induce downregulation of MYC by SPA, given that AR overexpression resulted in MYC downregulation in LAPC4 and 22Rv1 cells (Figure 1, D and F)

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However, this method also has recognized disadvantages in that a) the reaction steps are very complicated, and b) heavy metal compounds such as tetraacetyl lead must be employed

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