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[DOI] [PubMed] [Google Scholar] Lange SC, Bak LK, Waagepetersen HS, Schousboe A, Norenberg MD

However, developing engineered microbes as live biotherapeutic products presents considerable challenges in regulatory affairs, manufacturing, genetic stability, biocontainment, delivery, engraftment, and overall safety (135)

Therefore, although both nonenzymatic and enzymatic succinylations occur on GCLC, the latter mediated by P300, in cooperation with SIRT2, may play a major role in dynamically modulating the succinylation level of GCLC under stress condition

HoferTMarzettiEXuJSeoAGulecSKnutsonMet alIncreased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy