glutathione peroxidase helps the body convert Extracellular GPx3 and Its Role in Cancer Glutathione peroxidase 4‐dependent glutathione high‐consumption

Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury

Malkiewicz A

2025;241(7):e70062

DNA defects, epigenetics, and gene expression in cancer-adjacent breast: a study from the cancer genome atlas

A typical case is the development of glycogen synthase kinase-3 (GSK-3)/inhibitor of nuclear factor-B kinase- (IKK-) dual-target inhibitors, where the research team combined molecular docking with 200 ns MD simulation, not only verifying the binding stability of lead compounds but also discovering their unique hydrogen bond networks formed with the adenosine 5-triphosphate (ATP) binding pockets of both targets, ultimately achieving half maximal inhibitory concentration (IC 50 ) values of 12 nm and 8 nm for GSK-3 and IKK-, respectively (Roy Acharyya et al., 2022)