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The role of HMGB1 in MASLD is particularly associated with interactions between liver cells and immune cells

As a result, it remains uncertain whether similar effects would be observed in other pain phenotypes, such as nociplastic pain (e.g., fibromyalgia), nociceptive pain (e.g., osteoarthritis), or other neuropathic conditions (e.g., diabetic neuropathy)

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A 2011 study of 83 participants evaluated the effect of adding hand massage to multimodal behavior treatment of migraine and found that hand massage had no effect on migraine frequency