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In addition, intracellular oxidative damage can activate apoptosis via the C-Jun N-terminal kinase (JNK) pathway, a MAPk that activates p53

Usually felt in one leg, the sensation can be intolerable says Birgit Ruppert, a physical therapist at the Spine Center

Ethical statement The present retrospective study was approved by the Internal Review Boards (IRB) of the University Hospital of Modena (261/2023/OSS*/AOUMO)

To combat binder-induced constipation, patients are often advised to vastly increase their water intake, consume adequate dietary fiber, and utilize targeted supplements like magnesium citrate, vitamin C, or specialized prokinetics to keep the bowels moving