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10.1007/s00520-006-0153-3 74

Collectively, these findings support the efficacy of istradefylline at doses of 20 and 40 mg/day in reducing OFF time and improving motor function in PD patients with motor fluctuations [111]

Addictive drug abuse and histone acetylation Histone acetylation is a dynamic and reversible process occurring on all core histones, catalyzed by histone acetyltransferases and reversed by histone deacetylases (HDACs)