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When Your B12 Burns Out Too Fast If youre using methylcobalamin and feeling great for a few days then crashing, its probably burning out before your next shot

298 , E117E126 (2010)

In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited

Further, the elderly population is, as a statistical matter, at higher risk of malnutrition, as compared with younger adults