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The disulfide bonds are reversible, and they can again be reduced to thiol groups in proteins (e.g., protamine Cys residues) (152)

Managing these patients requires the development of new and effective molecular targets, drugs, and innovative therapeutic strategies

Table 5 and Figure 2)

Further evidence for the involvement of miRNAs in the mechanism of ECT comes from a study involving 64 patients with TRD: At baseline, expression of miRNA-223-3p was significantly lower in responders compared to non-responders and demonstrated moderate predictive capacity for ECT response (AUC = 0.76, 95% CI = 0.60.91) [28]

doi: 10.1016/j.intimp.2020.106565 118 ZhaoGZhouWLiuYWangYLiZSongZ