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Taking massive doses of poorly absorbed supplements can lead to digestive discomfort

Tested brands included Peets, DeathWish, Bulletproof, and 12 more.[article] A 2022 study found that 28% of green coffee beans (not roasted) had ochratoxin A contamination, but only 4% of the roasted coffees contained mycotoxin.[ref] Want to test a food or supplement yourself for mycotoxins

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Challenges include safety concerns (e.g., impaired wound healing from long-term MMP inhibition) and functional redundancy, where MMP-2 or MMP-12 might compensate for MMP-9 inhibition, necessitating multi-target inhibitors or combination therapies (Sang, 1998

The cells are constantly exposed to mechanical stress as they pass through the vascular system