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Other side effects may include: Skin that becomes lighter at the injection site Thinning of tissues around the site Nerve damage A temporary rise in blood sugarit may last for up to three weeks Joint infection Death of bone tissue near the site Hiccups Mood or mental health changessuch as anxiety, depression, difficulty sleeping, and hallucinations How to Recover From a Cortisone Shot Although the injection is quick, you may need to adjust your routine afterward: Avoid strenuous activities for 24 hours