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for example, the cytokine TNF- upregulates the level of the adhesion molecule VCAM-1

This immunological shift was mechanistically associated with inhibition of NF-B signaling and activation of PPAR, pathways well recognized for their opposing roles in inflammation and metabolic regulation ( 2 D 3 demonstrated modest reductions in hepatic mRNA expression of the pro-inflammatory cytokines TNF- and IL-6