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Overuse of stimulants : Excessive use of stimulants like caffeine can exacerbate HPA axis dysfunction, while smoking and alcohol can worsen inflammation, interfere with sleep, and have other negative effects

Schilder RJ, Hall L, Monks A, Handel LM, Fornace Jr AJ, Ozols RF, Fojo AT and Hamilton TC

Overexposure to aluminum may cause brain damage (encephalopathy)

Upon entering plant cells, NPs can induce ROS generation, which in turn activates transmembrane ion channels, antioxidant defense systems, and mitogen-activated protein kinases (MAPKs) 103,104

The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high fat diet-induced obesity