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Local IGF-I/IGF-IR signaling promotes the growth, survival and differentiation of chondrocytes and osteoblasts, directly and indirectly, by altering other autocrine/paracrine signaling pathways in cartilage and bone, and by enhancing interactions among these skeletal cells through hormonal and physical means

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The GH/IGF-1 system regulates glomerular hemodynamics, renal gluconeogenesis, tubular sodium and water, phosphate, and calcium handling, as well as renal synthesis of 1,25 (OH) 2 vitamin D 3 and the antiaging hormone Klotho

The activation of protein kinases may lead to the phosphorylation of transcription factors, which are proteins supporting gene expression

Impact of growth hormone hypersecretion on the adult human kidney