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Smoking Alcohol abuse Having endocrine-related autoimmune disorders (such as diabetes, or thyroid disorder) Gastrointestinal disorders such as Crohns disease Having undergone gastric bypass surgery or other surgeries that remove parts of the stomach

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Approximately 30% of patients experience the following adverse effects (6): Diarrhea Nausea Vomiting Less common adverse effects include (6): Headache Weakness Diaphoresis Hypoglycemia Dyspepsia Lactic acidosis, very rare 0.3/10000 cases Dysgeusia or complaints of a metallic taste Decrease appetite Vitamin B12 deficiency, absorption This may lead to subacute combined degeneration of the spine Higher risk for megaloblastic anemia The Black Box Warning for Biguanides alerts about the risk of lactic acidosis

Wiernicki, B

Drugs@FDA: search confirms no approved 5-Amino-1MQ product as of June 2026