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Also, the extrinsic factors of surrounding media such as PH, ionic strength and water hardness can influence the NP behavior in solution (Peretyazhko et al., 2014

TGF- synergizes with ML264 to block IL-1-induced matrix degradation mediated by Krppel-like factor 5 in the nucleus pulposus

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There is absolute chance of presence of undesirable particles or endotoxins in solution, so sterile filter is used in pharmaceutical industry to get rid of all of them