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Briefly, for the APTT assay, 50 L of APTT reagent (Beijing Reagan Biotechnology, China) and 50 L of plasma were mixed with 5 L of L-PC at different concentrations (0, 25, 50 M)

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This work was supported by Grants-in Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (23K27377, 22K11700, 22K19524, 21H05625, 24KK0150), Fusion Oriented Research for Disruptive Science and Technology (JST FOREST, JPMJFR2259), and the Japan Agency for Medical Research and Development (CREST, JP24gm1210009s0106)

Studies in inflammatory mice have shown that p -selectin is important for the initial rolling of neutrophils in the vessel wall and is required for neutrophil recruitment to sites of inflammation or infection (122)