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Karch J et al (2017) Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

The exact regulatory pathways are unclear, as in some settings vitamin E can activate or inhibit VEGF but it is thought to block effector mechanisms (Nussenblatt et al., 2006)

Unfortunately, the small sample size and the lack of thyroid function data of enrolled patients prevent drawing conclusions on this possible effect

10.1038/s41598-022-26915-3 505 ZhanX.StamovaB.JinL.-W.DeCarliC.PhinneyB.SharpF

Tylenol may play a role in some children, but the bigger picture includes genetics, microbiome, toxins, methylation, mitochondrial function, and nutrients