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In the UC developmental stage, macrophages predominantly exhibit the M1 phenotype, secreting pro-inflammatory factors that participate in the development of UC alongside the pro-inflammatory mediators they produce

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For growth assays, Synthetic Defined (SD) minimal media containing YNB (yeast nitrogen base), ammonium sulfate, and dextrose supplemented with histidine, leucine, lysine, and methionine (80 mg/liter) were used