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McFarlane called the approval of Miplyffa a monumental milestone for NPC patients and their family members in the U.S

The dose ceiling of 2.4 mg represents the point where increasing the dose further produces diminishing returns with escalating gastrointestinal problems

If you are tolerating the medication well and losing 1.52 lbs per week consistently, there is no reason to increase your dose

71,72 To account for differences between drugs, such as the 1 AR antagonist activity of carvedilol, we ran sensitivity analyses with each drug removed and found similar risks (data not shown), suggesting that our results cannot be attributed to any single compound

Dahl, L