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Thus, glutathione reductase activity reflected by the erythrocyte glutathione reductase activity coefficient is frequently used as a measure of riboflavin status (135, 287)

While these bacterial enzymes have been explored for the generation of natural product analogs or applications in biocatalysis, the broad utility of amide bond-forming enzymes in enzymatic combinatorial synthesis has not been fully realized because of unwanted cross-reactivities of the enzymes toward substrates and/or difficulties in finding partnering enzymes with comparable substrate promiscuity 56

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It also enhanced insulin sensitivity, as evidenced by increased plasma insulin levels and decreased HOMA-IR values