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The Consensus Molecular Subtypes of Colorectal Cancer

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analyzed the effects of Isatuximab, the second anti-CD38 reagent approved by the FDA, on NK cells, which express CD16, a low affinity FcR ( Overall, these results suggest that some of the therapeutic actions of the antibody are mediated by direct signaling through the CD38 molecule, without the effects driven by FcRs, at least in the NK cells tested in vitro

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Why it matters: Testing both IGF-1 and IGFBP-3 together provides a more complete picture of growth hormone activity

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10.1016/j.neuroscience.2012.09.073 Neuroscience 148 NumakawaT.KajiharaR

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