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The influence of HO-1 on the TME immunoprofile was highlighted by Alaluf et al., who reported that myeloid-specific ablation of HO-1 induced global transcriptional and epigenetic alterations not limited to the conventional M1/M2 polarization state of TAMs, but rather leading to extensive dysregulation of the central molecular signature of the TME (45)

While it can be nothing more than speculation because of the small sample size, patients who showed therapeutic effects following glutathione treatment appeared to be younger and did not have diabetes or had mild diabetes

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