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The results showed that, in all fibroblasts, the tM1 coefficient is always higher than tM2 (Figure 4C), which indicates that the percentage of mitochondria being labeled for degradation is higher than the percentage of p62/SQSTM1 that is intended to mark those mitochondria (that is, there is a certain percentage of p62/SQSTM1 that remains free to mark other substrates for degradation)

National Library of Medicine (2026)

report that riboside catalpol can activate antioxidant enzymes (such as superoxide dismutase (SOD) and catalase (CAT), reduce the level of oxidative stress in the body, and protect cells (26)