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GHK-Cu exerts broad anti-inflammatory effects through its influence on approximately 31% of the human genome, specifically downregulating genes involved in inflammatory processes including interleukin-1, tumor necrosis factor-, and nuclear factor-B (NF-B) signaling while upregulating protective genes encoding antioxidant enzymes, DNA repair proteins, and anti-inflammatory mediators

Globally, approximately 15%25% of diabetic individuals will develop a foot ulcer during their lifetime, a significant proportion of which progress to chronic, non-healing wounds, leading to amputation or death (Cano Sanchez et al., 2018

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One aliquot was analysed immediately with a Spincell 3 haematology analyser (Monlab), while others were centrifuged at 23,000 g for 10 min at room temperature in a Sigma 112 mini centrifuge to obtain plasma

This approach necessitates further research into the molecular mechanisms of redox signaling