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Description

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus

A., Eliasziw, M., Cattran, D

What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

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Additional laboratory investigations examine cellular methylation-related pathways and NAD-associated signaling systems , which play a role in cellular energy dynamics and metabolic pathway coordination in controlled experimental settings