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Cardiotoxicity Two small RCTs: Conflicting results, one showed no effect, one showed reduced cardiac events

Alison Steiber, Janos Kerner, Charles L Hoppel

MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]